The Two Medicine Fight Site struggle on July 27, 1806 was the only violent conflict between the Corps of Discovery and Native Americans and resulted in the only two Indian casualties of the Expedition. Furthermore, it marks the first meeting and conflict between any representative of the American government and the Blackfeet Nation.

The Two Medicine Fight Site was added to the National Register of Historic Places in 1970. Today, the Two Medicine Fight Site is still in the Blackfeet Indian territory on the Blackfeet Indian Reservation. To access the site, permission is required.